Homology Model of Human FIXa


All structural analysis of the mutations presented within this database uses the homology model of FIXa (FIXa_HUMAN.pdb) that was generated by us from the experimental structures available for the 4 domains individually.

The PDB codes of the experimental structures for these 4 human domains are: Gla domain (PDB code: 1CFI), the EGF1 domain (PDB code: 1EDM) and the EGF2-SP domain pair (PDB code: 3KCG).


Experimental Structures available for HUMAN Coagulation Factor IX


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

1CFH NMR STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY TWO-DIMENSIONAL NMR SPECTROSCOPY - A 47-93 >>
1CFI NMR NMR STRUCTURE OF CALCIUM ION-BOUND GAMMA-CARBOXY-GLUTAMIC ACID-RICH DOMAIN OF FACTOR IX - A 47-93 >>
1EDM X-ray EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX 1.50 B/C 92-130 >>
1IXA NMR THE THREE-DIMENSIONAL STRUCTURE OF THE FIRST EGF-LIKE MODULE OF HUMAN FACTOR IX: COMPARISON WITH EGF AND TGF-A - A 92-130 >>
1MGX NMR COAGULATION FACTOR, MG(II), NMR, 7 STRUCTURES (BACKBONE ATOMS ONLY) - A 47-93 >>
1NL0 X-ray Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12 2.20 G 47-91 >>
1RFN X-ray HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE 2.80 A 227-461 >>
1RFN X-ray HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE 2.80 B 133-188 >>
2WPH X-ray FACTOR IXA SUPERACTIVE TRIPLE MUTANT 1.50 E 133-191 >>
2WPH X-ray FACTOR IXA SUPERACTIVE TRIPLE MUTANT 1.50 S 227-461 >>
2WPI X-ray FACTOR IXA SUPERACTIVE DOUBLE MUTANT 1.99 E 133-191 >>
2WPI X-ray FACTOR IXA SUPERACTIVE DOUBLE MUTANT 1.99 S 227-461 >>
2WPJ X-ray FACTOR IXA SUPERACTIVE TRIPLE MUTANT, NACL-SOAKED 1.60 E 133-191 >>
2WPJ X-ray FACTOR IXA SUPERACTIVE TRIPLE MUTANT, NACL-SOAKED 1.60 S 227-461 >>
2WPK X-ray FACTOR IXA SUPERACTIVE TRIPLE MUTANT, ETHYLENE GLYCOL-SOAKED 2.21 E 133-191 >>
2WPK X-ray FACTOR IXA SUPERACTIVE TRIPLE MUTANT, ETHYLENE GLYCOL-SOAKED 2.21 S 227-461 >>
2WPL X-ray FACTOR IXA SUPERACTIVE TRIPLE MUTANT, EDTA-SOAKED 1.82 E 133-191 >>
2WPL X-ray FACTOR IXA SUPERACTIVE TRIPLE MUTANT, EDTA-SOAKED 1.82 S 227-461 >>
2WPM X-ray FACTOR IXA SUPERACTIVE MUTANT, EGR-CMK INHIBITED 2.00 E 133-191 >>
2WPM X-ray FACTOR IXA SUPERACTIVE MUTANT, EGR-CMK INHIBITED 2.00 S 227-461 >>
3KCG X-ray Crystal structure of the antithrombin-factor IXa-pentasaccharide complex 1.70 H 227-461 >>
3KCG X-ray Crystal structure of the antithrombin-factor IXa-pentasaccharide complex 1.70 L 131-188 >>
3LC3 X-ray Benzothiophene Inhibitors of Factor IXa 1.90 A/C 227-461 >>
3LC3 X-ray Benzothiophene Inhibitors of Factor IXa 1.90 B/D 133-188 >>
3LC5 X-ray Selective Benzothiophine Inhibitors of Factor IXa 2.62 A 227-461 >>
3LC5 X-ray Selective Benzothiophine Inhibitors of Factor IXa 2.62 B 133-188 >>


Experimental Structures available for porcine Coagulation Factor IX


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

1PFX X-ray X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. 3.00 L 1-146 >>
1PFX X-ray X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. 3.00 C 183-410 >>
1X7A X-ray SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa. 2.90 L 1-146 >>
1X7A X-ray SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa. 2.90 C 183-410 >>


Experimental Structures available for bovine Coagulation Factor IX


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

1J34 X-ray Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein. 1.55 C 1-46 >>
1J35 X-ray Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein. 1.80 C 1-46 >>